Nasal Sinus Surgery Improves Lower Airway Reactivity during Aspirin Desensitization for AERD
نویسندگان
چکیده
منابع مشابه
The clinical effectiveness of aspirin desensitization in chronic rhinosinusitis.
Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized by chronic rhinosinusitis, nasal polyposis, asthma, and airway reactivity to aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs). For patients who have inadequately controlled rhinosinusitis and/or asthma despite treatment with topical corticosteroids and leukotriene-modifying drugs, aspiri...
متن کاملUpdate on the Management of Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) is an adult-onset upper and lower airway disease consisting of eosinophilic nasal polyps, asthma, and respiratory reactions to cyclooxygenase 1 (COX-1) inhibitors. Management includes guideline-based treatment of asthma and sinus disease, avoidance of COX-1 inhibitors, and for some patients aspirin desensitization followed by high-dose aspirin ther...
متن کاملThe role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD).
INTRODUCTION Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options. OBJECTIVE To evaluate the efficacy and tolerability of aspirin desensitization in patien...
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in healthy volunteers. Levocetirizine reduces plasmatic level of IL-6 (1.19 versus 1.006, P 1⁄4 0.0097) and IL-8 (8.90 versus 6.90, P 1⁄4 0.0003) after 4 weeks treatment, while Desloratadine has influence only IL-6 level (1.68 versus 1.36, P 1⁄4 0.0038). The intergroup analysis revealed no significant difference between these 2 drugs regarding IL-6 (P 1⁄4 0.36) and IL-8 (P 1⁄4 0.25). Conclusion...
متن کاملClinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease
This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2018.12.866